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Disease can cause constipation it also includes diabetes, multiple sclerosis, digestive disorders like irritable bowel syndrome, and even spinal cord injuries. If your constipation is not caused by a disease, it is most likely caused by a dietary or environmental stressor. The easiest way to remove diet as a possible stressor is to temporarily remove all meat from your food intake. If constipation is eliminated when doing this, then it would be safe to conclude that your diet was the cause of constipation. Besides having the diseases, constipation can be your body alarm telling you that it is time for a colon cleanse.